Osmium in PDB 7ffm: Human Serum Transferrin with Five Osmium Binding Sites

The structure of Human Serum Transferrin with Five Osmium Binding Sites, PDB code: 7ffm was solved by M.Wang, H.Sun, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.77 / 3.06
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	137.954, 158.211, 107.102, 90, 90, 90
R / Rfree (%)	18 / 21.2

The structure of Human Serum Transferrin with Five Osmium Binding Sites also contains other interesting chemical elements:

Titanium

(Ti)

1 atom

The binding sites of Osmium atom in the Human Serum Transferrin with Five Osmium Binding Sites (pdb code 7ffm). This binding sites where shown within 5.0 Angstroms radius around Osmium atom.
In total 5 binding sites of Osmium where determined in the Human Serum Transferrin with Five Osmium Binding Sites, PDB code: 7ffm:
Jump to Osmium binding site number: 1; 2; 3; 4; 5;

Osmium binding site 1 out of 5 in the Human Serum Transferrin with Five Osmium Binding Sites


Mono view


Stereo pair view

A full contact list of Osmium with other atoms in the Os binding site number 1 of Human Serum Transferrin with Five Osmium Binding Sites within 5.0Å range: probe atom residue distance (Å) B Occ A:Os704 b:119.4 occ:0.75 NE2 A:HIS14 2.3 51.6 1.0 NE2 A:HIS289 2.5 103.6 1.0 O9 A:NTA703 2.6 100.7 1.0 O5 A:NTA703 2.7 103.9 1.0 O A:HOH802 2.8 50.6 1.0 N1 A:NTA703 2.8 96.5 1.0 CE1 A:HIS14 3.2 64.1 1.0 CE1 A:HIS289 3.2 104.5 1.0 C3 A:NTA703 3.2 103.8 1.0 C2 A:NTA703 3.3 101.1 1.0 O13 A:NTA703 3.3 87.8 1.0 CD2 A:HIS14 3.3 42.4 1.0 CD2 A:HIS289 3.4 97.6 1.0 C7 A:NTA703 3.4 97.5 1.0 C6 A:NTA703 3.6 96.3 1.0 C11 A:NTA703 3.8 88.8 1.0 C10 A:NTA703 3.9 90.1 1.0 O4 A:NTA703 4.1 99.6 1.0 ND1 A:HIS289 4.2 96.9 1.0 ND1 A:HIS14 4.3 54.6 1.0 CG A:HIS289 4.3 92.3 1.0 CG A:HIS14 4.4 24.7 1.0 O8 A:NTA703 4.6 92.5 1.0 O12 A:NTA703 4.7 91.2 1.0

Osmium binding site 2 out of 5 in the Human Serum Transferrin with Five Osmium Binding Sites


Mono view


Stereo pair view

A full contact list of Osmium with other atoms in the Os binding site number 2 of Human Serum Transferrin with Five Osmium Binding Sites within 5.0Å range: probe atom residue distance (Å) B Occ A:Os705 b:104.7 occ:0.50 O A:HOH810 2.5 84.6 1.0 NZ A:LYS490 2.6 89.3 1.0 OE1 A:GLU507 2.7 82.8 1.0 O A:HOH809 2.7 47.1 1.0 CD A:GLU507 3.3 74.0 1.0 OS A:OS706 3.7 141.1 0.6 CE A:LYS490 3.8 78.8 1.0 CG A:GLU507 3.9 52.3 1.0 OE2 A:GLU507 4.0 80.9 1.0 O A:HOH811 4.3 94.2 1.0 O A:HOH812 4.3 55.8 1.0 CD A:LYS490 4.7 82.9 1.0 CG A:LYS490 4.9 75.8 1.0

Osmium binding site 3 out of 5 in the Human Serum Transferrin with Five Osmium Binding Sites


Mono view


Stereo pair view

A full contact list of Osmium with other atoms in the Os binding site number 3 of Human Serum Transferrin with Five Osmium Binding Sites within 5.0Å range: probe atom residue distance (Å) B Occ A:Os706 b:141.1 occ:0.58 O A:HOH811 2.4 94.2 1.0 O A:HOH812 2.8 55.8 1.0 O A:HOH810 2.8 84.6 1.0 NZ A:LYS489 3.1 87.6 1.0 OS A:OS705 3.7 104.7 0.5 O A:HOH809 4.3 47.1 1.0 CE A:LYS489 4.5 86.2 1.0 CD A:LYS489 4.9 89.0 1.0

Osmium binding site 4 out of 5 in the Human Serum Transferrin with Five Osmium Binding Sites


Mono view


Stereo pair view

A full contact list of Osmium with other atoms in the Os binding site number 4 of Human Serum Transferrin with Five Osmium Binding Sites within 5.0Å range: probe atom residue distance (Å) B Occ A:Os707 b:113.7 occ:0.44 NE2 A:HIS578 2.1 137.4 1.0 NH2 A:ARG581 2.6 76.6 0.4 CD2 A:HIS578 2.8 117.2 1.0 O A:HOH806 2.8 32.1 1.0 CE1 A:HIS578 3.2 126.7 1.0 CZ A:ARG581 3.6 77.1 0.4 CG A:HIS578 4.0 109.8 1.0 CG A:ARG581 4.2 71.0 0.4 ND1 A:HIS578 4.2 121.0 1.0 NH1 A:ARG581 4.3 79.3 0.4 NE A:ARG581 4.3 76.6 0.4 CD A:ARG581 4.4 72.9 0.4 CE2 A:PHE427 4.5 94.3 1.0

Osmium binding site 5 out of 5 in the Human Serum Transferrin with Five Osmium Binding Sites


Mono view


Stereo pair view

A full contact list of Osmium with other atoms in the Os binding site number 5 of Human Serum Transferrin with Five Osmium Binding Sites within 5.0Å range: probe atom residue distance (Å) B Occ A:Os708 b:111.1 occ:0.30 O A:HOH805 2.3 102.0 1.0 CE1 A:HIS349 2.3 136.4 1.0 NE2 A:HIS350 2.4 136.8 1.0 ND1 A:HIS349 2.5 137.3 1.0 O A:HOH808 2.7 111.4 1.0 O A:HOH807 2.8 71.5 1.0 CE1 A:HIS350 3.0 135.3 1.0 CD2 A:HIS350 3.2 133.9 1.0 NE2 A:HIS349 3.6 138.6 1.0 CG A:HIS349 3.8 140.0 1.0 ND1 A:HIS350 4.0 135.1 1.0 CG A:HIS350 4.1 131.1 1.0 CD2 A:HIS349 4.3 141.3 1.0 CB A:HIS349 4.8 129.4 1.0

M.Wang, H.Wang, X.Xu, T.P.Lai, Y.Zhou, Q.Hao, H.Li, H.Sun. Binding of Ruthenium and Osmium at Non‐Iron Sites of Transferrin Accounts For Their Iron-Independent Cellular Uptake. J.Inorg.Biochem. V. 234 11885 2022.
ISSN: ISSN 0162-0134
PubMed: 35690040
DOI: 10.1016/J.JINORGBIO.2022.111885